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Cerebrolysin is a mix of enzymatically treated neuropeptides (20%) and amino acids (80%) derived from pig brains. Its constituents can include low molecular weight neuropeptides that are similar to fragments of natural neurotrophic factors (NTF), for example, ciliary neurotrophic factor (CNTF), brain-derived neurotrophic factor (BDNF), glial cells derived neurotrophic factor (GDNF), nerve growth factor (NGF), and insulin-like growth factor (IGF).

Cerebrolysin has been studied for potential use in a wide variety of neurodegenerative disorders, such as dementia including Alzheimer’s disease, stroke, and traumatic brain injury (TBI).

Cerebrolysin is available in different ampoule sizes: from 2ml to 20ml. We offer worldwide shipping!

Generic name:Cerebrolysin, FPF-1070
Form:Solution for intramuscular and intravenous injections in ampoules/vials.
Form description:Transparent solution of amber color
Active ingredient:215.2 mg of Cerebrolysin concentrate in an aqueous solution
Excipients:Sodium hydroxide and water for injection
СAS Number:12656-61-0
ATC code:N06ВХ Nootropics
Shelf life:5 years. Do not use it beyond the expiration date printed on the package.
Storage:Store at temperatures not exceeding 25°C (77°F). Do not freeze. Protect from light.
Manufacturer:EVER Pharma, Austria. www.everpharma.com

What is Cerebrolysin Used For?

Cerebrolysin is a neuropeptide preparation with neuroprotective and neurorestorative effects. In some countries this “smart drug” is used in the complex treatment of cerebrovascular disorders:

  • Strokes and stroke complications;
  • Alzheimer’s disease and other types of dementia;
  • Traumatic brain injuries;
  • Spinal cord injuries;
  • ADHD in children;
  • Antidepressant-resistant depressions;
  • Other brain diseases.

What are Cerebrolysin Benefits?

According to the manufacturer, Cerebrolysin is used in the complex treatment of acute and chronic disorders of the central nervous system (CNS). It supports endogenous repair and recovery processes after an injury or degenerative disease. It also helps to protect the brain against pathological events and cascades. Cerebrolysin mechanism of action resides in its ability to activate endogenous defense mechanisms (ESM), which include four main components: 1) Neurotrophic, 2) Neuroprotection, 3) Neuroplasticity, and 4) Neurogenesis.

As practice shows, repeated and long-term courses of treatment with Cerebrolysin peptide lead to an increase in the effectiveness of neuro-therapy, especially in relation to improved cognitive and behavioral functions.

In clinical practice, Cerebrolysin is known to reduce symptoms of depression, cognitive impairment, and autonomic disorders. It is said to relieve pain syndrome and enhance the effect of tricyclic antidepressants.

Is Cerebrolysin Safe to Take?

Cerebrolysin has an excellent safety record. Unless taken in large amounts (>10 ml), adverse reactions are mild and rare.

Special attention shall be taken when stacking Cerebrolysin with antidepressants, including MAO inhibitors.

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Authentic Cerebrolysin ampoules for injection are available at CosmicNootropic. We offer the most popular forms: Cerebrolysin 5ml and Cerebrolysin 10ml ampoules as well as other volumes depending on the purpose of use.

You do not need a prescription to obtain Cerebrolysin online. Buy it with worldwide delivery. CosmicNootropic offers bulk discounts 👍

Check out our blog post
🧠 Comprehensive Cerebrolysin Review with FAQ Section 🧠

Legal Disclaimer
This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

What is the Optimal Cerebrolysin Dosage?

Cerebrolysin has indication-specific dosing. The most common regime for improving brain function is IM injections of 5 ml daily.The course of treatment is 4 weeks unless otherwise prescribed by your attending physician.

Dose recommendations from the manufacturer:

ConditionDosage When to start Duration
Stroke20 – 50 ml / as soon as possible/ 10 – 21 days
Vascular dementia10 – 30 ml / as soon as possible/ 1 cycle: 5 days a week/ 4 weeks, 2-4 cycles per year
Alzheimer’s disease10 – 30 ml / as soon as possible/ 1 cycle: 5 days a week/ 4 weeks, 2-4 cycles per year
TBI20 – 50 ml / as soon as possible/ 7 – 30 days

How to Inject Cerebrolysin?

The main ways of administering the drug are intramuscular (IM) and intravenous (IV). The gluteal region is the best spot to inject IM. Relax your muscle and inject slowly. Here are a couple of tips on how to make injections. Please follow the sterility instructions!

What are Cerebrolysin Side Effects?

Rare cases of adverse reactions to Cerebrolysin may include fatigue, headaches, dizziness, insomnia, etc.

Please note that it is important to follow the recommendations of the drug administration to minimize the chance of adverse reactions.

The drug is injected slowly. If the injection is made too fast, in rare cases, there can be a feeling of heat, sweating, dizziness, heart palpitations, or arrhythmia.

Cerebrolysin is reported to lose its effectiveness when used for longer than necessary. However, there are anecdotal cases of Cerebrolysin causing anxiety, headaches, and aches in the body when the medication brings no benefit any longer.

CEREBROLYSIN OFFICIAL INSTRUCTION

  1. Rutheret al (1994) Efficacy of the Peptidergic Nootropic Drug Cerebrolysin in Patients with Senile Dementia of the Alzheimer Type (SDAT) https://www.ncbi.nlm.nih.gov/pubmed/8159781
  2. L. Francis-Turner, V. Valouskova (1996) Nerve growth factor and nootropic drug Cerebrolysin but not fibroblast growth factor can reduce spatial memory impairment elicited by fimbria-fornix transection: short-term study https://www.ncbi.nlm.nih.gov/pubmed/8848264
  3. Schwab et al (1997) Morphofunctional effects of moderate forebrain ischemia combined with short-term hypoxia in rats – protective effects of Cerebrolysin https://www.ncbi.nlm.nih.gov/pubmed/9085071
  4. V. Valouskova and A. Gschanes (1999) Effects of NGF, b-FGF, and Cerebrolysin on Water Maze Performance and on Motor Activity of Rats: Short- and Long-Term Study https://www.ncbi.nlm.nih.gov/pubmed/10082636
  5. Masliah et al (1999) Cerebrolysin Ameliorates Performance Deficits, and Neuronal Damage in Apolipoprotein E-Deficient Mice https://www.ncbi.nlm.nih.gov/pubmed/9972690
  6. Bae et al (2000) A Double-Blind, Placebo-Controlled, Multicenter Study of Cerebrolysin for Alzheimer’s Disease https://www.ncbi.nlm.nih.gov/pubmed/11129744
  7. Ruther et al (2000) Sustained improvements in patients with dementia of Alzheimer’s type (DAT) 6 months after termination of Cerebrolysin therapy https://www.ncbi.nlm.nih.gov/pubmed/11005546
  8. Ruether et al (2001) A 28-week, double-blind, placebo-controlled study with Cerebrolysin in patients with mild to moderate Alzheimer’s disease https://www.ncbi.nlm.nih.gov/pubmed/11552768
  9. Hartbauer et al (2001) Antiapoptotic effects of the peptidergic drug Cerebrolysin on primary cultures of embryonic chick cortical neurons https://www.ncbi.nlm.nih.gov/pubmed/11475013
  10. Hartbauer et al (2001) Effects of Cerebrolysin on the outgrowth and protection of processes of cultured brain neurons https://www.ncbi.nlm.nih.gov/pubmed/11459078
  11. Eder et al (2001) Increased density of glutamate receptor subunit 1 due to Cerebrolysin treatment: An immunohistochemical study on aged rats https://www.ncbi.nlm.nih.gov/pubmed/12197668
  12. Panisset et al (2002) Cerebrolysin in Alzheimer’s disease: a randomized, double-blind, placebo-controlled trial with a neurotrophic agent https://www.ncbi.nlm.nih.gov/pubmed/12111446
  13. Rockenstein et al (2003) The neuroprotective effects of Cerebrolysin in a transgenic model of Alzheimer’s disease are associated with improved behavioral performance https://www.ncbi.nlm.nih.gov/pubmed/14628195
  14. Ladurner et al (2004) Neuroprotective treatment with Cerebrolysin in patients with acute stroke: a randomised controlled trial https://www.ncbi.nlm.nih.gov/pubmed/15583955
  15. Alvarez et al (2006) A 24-week, double-blind, placebo-controlled study of three dosages of Cerebrolysin in patients with mild to moderate Alzheimer’s disease https://www.ncbi.nlm.nih.gov/pubmed/16420392
  16. Rockenstein et al (2006) Cerebrolysin Decreases Amyloid-b Production by Regulating Amyloid Protein Precursor Maturation in a Transgenic Model of Alzheimer’s Disease https://www.ncbi.nlm.nih.gov/pubmed/16511867
  17. Wei et al (2007) Meta-analysis: the efficacy of nootropic agent Cerebrolysin in the treatment of Alzheimer’s disease https://www.ncbi.nlm.nih.gov/pubmed/17318304
  18. Ren et al (2007) Cerebrolysin enhances functional recovery following focal cerebral infarction in rats https://www.ncbi.nlm.nih.gov/pubmed/17473393
  19. Alvarez et al (2008) Reductions in qEEG slowing over 1 year and after treatment with Cerebrolysin in patients with moderate–severe traumatic brain injury https://www.ncbi.nlm.nih.gov/pubmed/18273537
  20. Muresanu et al (2008) A pilot study to evaluate the effects of Cerebrolysin on cognition and qEEG in vascular dementia: Cognitive improvement correlates with qEEG acceleration https://www.ncbi.nlm.nih.gov/pubmed/18048059
  21. Alvarez et al (2009) Reduced TNF-a and increased IGF-I levels in the serum of Alzheimer’s disease patients treated with the neurotrophic agent Cerebrolysin https://www.ncbi.nlm.nih.gov/pubmed/19531281
  22. Sharma et al (2010) Cerebrolysin reduces blood-cerebrospinal fluid barrier permeability change, brain pathology, and functional deficits following traumatic brain injury in the rat https://www.ncbi.nlm.nih.gov/pubmed/20633118
  23. Guekht et al (2011) Cerebrolysin in Vascular Dementia: Improvement of Clinical Outcome in a Randomized, Double-Blind, Placebo-Controlled Multicenter Trial https://www.ncbi.nlm.nih.gov/pubmed/20656516
  24. Alcantara-Gonzalez et al (2012) Combined Administration of Cerebrolysin and Donepezil Induces Plastic Changes in Prefrontal Cortex in Aged Mice https://www.ncbi.nlm.nih.gov/pubmed/22826038
  25. Heiss (2012) Cerebrolysin in Patients With Acute Ischemic Stroke in Asia Results of a Double-Blind, Placebo-Controlled Randomized Trial https://www.ncbi.nlm.nih.gov/pubmed/22282884
  26. Menon et al (2012) Cerebrolysin, a Mixture of Neurotrophic Factors Induces Marked Neuroprotection in Spinal Cord Injury Following Intoxication of Engineered Nanoparticles from Metals https://www.ncbi.nlm.nih.gov/pubmed/22229324
  27. Chen et al (2013) Cerebrolysin enhances cognitive recovery of mild traumatic brain injury patients: double-blind, placebo-controlled, randomized study https://www.ncbi.nlm.nih.gov/pubmed/23656173
  28. Amiri-Nikpour et al (2014) Cerebrolysin effects on neurological outcomes and cerebral blood flow in acute ischemic stroke https://www.ncbi.nlm.nih.gov/pubmed/25516711
  29. Muresanu et al (2015) Cerebrolysin and Recovery After Stroke (CARS) A Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial https://www.ncbi.nlm.nih.gov/pubmed/26564102
  30. Ziganshina et al (2016) Cerebrolysin for acute ischaemic stroke https://www.ncbi.nlm.nih.gov/pubmed/27918088
  31. Chutko et al (2017) [The efficacy of cerebrolysin in the treatment of autism spectrum disorders] https://pubmed.ncbi.nlm.nih.gov/29053124/
  32. M Brainin (2018) Cerebrolysin: a multi-target drug for recovery after stroke https://pubmed.ncbi.nlm.nih.gov/30004268/
  33. Torshin et al (2019) [Cerebrolysin peptides as mood stabilizers] https://pubmed.ncbi.nlm.nih.gov/31994517/
  34. Alzoubi et al (2020) Cerebrolysin prevents sleep deprivation induced memory impairment and oxidative stress https://pubmed.ncbi.nlm.nih.gov/31987894/
  35. S Gavrilova, A Alvarez (2021) Cerebrolysin in the therapy of mild cognitive impairment and dementia due to Alzheimer’s disease: 30 years of clinical use https://pubmed.ncbi.nlm.nih.gov/32808294/
  36. Strilciuc et al (2021) Safety of Cerebrolysin for Neurorecovery after Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of Twelve Randomized-Controlled Trials https://pubmed.ncbi.nlm.nih.gov/34959697/
  37. Mureșanu et al (2022) The Effect of Cerebrolysin on Anxiety, Depression, and Cognition in Moderate and Severe Traumatic Brain Injury Patients: A CAPTAIN II Retrospective Trial Analysis https://pubmed.ncbi.nlm.nih.gov/35630065/
  38. Villarreal-Reyna et al (2022) Cerebrolysin induces hair repigmentation associated to MART-1/Melan-A reactivation https://pubmed.ncbi.nlm.nih.gov/36411485/

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FAQs

Is Cerebrolysin available in the US? ›

It is not an approved drug in the United States.

Does Cerebrolysin require a prescription? ›

Cerebrolysin® is a prescription medication.

Does cerebrolysin affect the kidneys? ›

For patients with “severe renal impairment” a Cerebrolysin treatment is contraindicated. Based on the classification of „severe renal insufficiency”, Cerebrolysin should not be administered to patients with a GFR category stages 4 and 5.

What does cerebrolysin do to the brain? ›

Cerebrolysin ® is a multi-modal neuropeptide drug which improves the brain's ability for self-repair by stimulating neurorecovery.

Is cerebrolysin approved by the FDA? ›

While Cerebrolysin is approved for use in Austria, China, Germany, Russia and South Korea, the FDA has yet to approve it for use in the United States.

Is Zuclopenthixol available in the US? ›

Zuclopenthixol brand names

Zuclopenthixol is not approved by the FDA for sale in the United States. It is available internationally under the following brand names: Clopixol. Clopixol Acuphase.

How many mg is a 10ml injection of cerebrolysin? ›

Cerebrolysin 10 Ml Injection (Cerebroprotein Hydrolysate (215.2mg)

What are the side effects of cerebrolysin 1ml? ›

It is not known to cause serious side effects but injection site reaction (pain or redness), nausea, headache and vertigo may occur. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.

How safe is cerebrolysin? ›

Cerebrolysin ® is safe and well tolerated!

In general, reported adverse drug reactions are transient and mild in intensity. Please note that the handling is very important.

Are cerebrolysin and cerebroprotein the same? ›

Cerebroprotein hydrolysate is the common active ingredient of all the tested peptide preparations except Aktoseril, Cerebropept, and the originator product Cerebrolysin. Since the compounds could not induce NF-L expression like Cerebrolysin did, we assumed their peptide composition might also differ.

What class of drug is cerebrolysin? ›

Cerebrolysin Injection contains Cerebroprotein Hydrolysate, a medication from the class of drugs known as central nervous system agents, which is used to treat head injuries, strokes, and aprosexia in dementia by enhancing nerve survival and preventing nerve damage.

Who makes cerebrolysin? ›

The trial was supported by the manufacturer of cerebrolysin, EVER Neuro Pharma GmbH.

Is Pexion available in the US? ›

Imepitoin ( INN Tooltip International Nonproprietary Name), sold under the brand name Pexion, is an anticonvulsant which is used in veterinary medicine in Europe to treat epilepsy in dogs. It was recently approved in the United States. The drug also has anxiolytic effects.

Is piracetam legal in the US? ›

Overview. Piracetam is a lab-made chemical. In Europe, it is a prescription drug used to improve brain function. It is not approved as a drug or supplement in the US.

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